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. 2016 Nov 16;17(11):1919. doi: 10.3390/ijms17111919

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of a mixture of extracts of Kochia scoparia and Rosa multiflora (KR) on dermal collagen density in photoaging murine skin. To evaluate collagen density in the dermis, Masson-trichrome staining was performed in photoaging skin treated with topical KR, vehicle (veh), or tesaglitazar (Tes) for 8 weeks (A); we used the histogram function of Photoshop^® software to evaluate collagen density (B). In photoaging murine skin, dermal collagen densities did not significantly change with either KR or Tes treatment; Scale bar = 100 µm.