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. 2016 Nov 17;17(11):1927. doi: 10.3390/ijms17111927

Figure 5.

Figure 5

Effect of PTE on mitogen-activated protein kinase (MAPK) signaling pathway. (A) H929 cells were treated with PTE (10, 20, and 40 μM) for 48 h and the levels of extracellular regulated protein kinases (ERK) 1/2, phospho-ERK1/2, p38 MAPK, phospho-p38 MAPK, c-Jun N-terminal kinase (JNK), phospho-JNK, c-Jun and phospho-c-Jun assessed by Western blot; and (B) pretreatment with U0126, and SP600125 (10 μM each) for 3 h, after which H929 cells were treated with 40 μM PTE and the levels of cleaved caspase 3 assessed by Western blot.