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. 2016 Nov 18;17(11):1928. doi: 10.3390/ijms17111928

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Anti-cancer effect of TSN on U87 cells in vivo. (A,B) U87-Luc cells were subcutaneously implanted into six-week-old athymic nude mice, and the mice were treated with either TSN or vehicle. The volume of the xenograft tumors was measured daily. After 10 days of treatment, the tumor nodules were isolated and weighted; (C) Measurement of the bioluminescence signal by intraperitoneal injection of D-Luciferin. Representative images and statistical analysis of the luminescence are illustrated (* p < 0.05); (D) Histological analysis of U87 cell proliferation and apoptosis by Ki67 staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay (* p < 0.05). Scale bar indicates 100 µm.

Anti-cancer effect of TSN on U87 cells in vivo. (A,B) U87-Luc cells were subcutaneously implanted into six-week-old athymic nude mice, and the mice were treated with either TSN or vehicle. The volume of the xenograft tumors was measured daily. After 10 days of treatment, the tumor nodules were isolated and weighted; (C) Measurement of the bioluminescence signal by intraperitoneal injection of D-Luciferin. Representative images and statistical analysis of the luminescence are illustrated (* p < 0.05); (D) Histological analysis of U87 cell proliferation and apoptosis by Ki67 staining and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay (* p < 0.05). Scale bar indicates 100 µm.