Figure 2.

Transgenic (TG) zebrafish as a biosensor for toxicant identification. The modern toxicological approach takes advantage of biotechnological techniques, which allow the development of various zebrafish transgenic lines equipped with the reporter genes such as green fluorescent protein (GFP). Induction of reporter gene expression is driven by specific response elements providing the possibility for demonstration of the tissue-specific mode of toxicant action. These methods have improved the sensitivity and effectiveness of detection in comparison to traditional toxicological techniques. These types of genetically modified zebrafish lines are excellent biosensors and are used for precise qualitative and quantitative analysis of a wide range of potential toxicants.