Figure 3.

Effects of three APDs on D₁ and D₂ receptor expression levels in the Hippocampus (D₁R: (A’,A”); D₂R: (B’,B”)) and VTA (D₁: (C’,C”); D₂: (D’,D”)) of female and male rats. Sprague-Dawley rats were treated chronically with Aripiprazole (1.0 mg/kg, t.i.d), Olanzapine (1.0 mg/kg, t.i.d), Risperidone (0.3 mg/kg, t.i.d) or control (vehicle). Data expressed as mean ± SEM. *** p < 0.001 vs. control. The representative bands of Western blot are shown. APD: Antipsychotic drug; Hipp: Hippocampus; t.i.d.: Three times daily; VTA: Ventral Tegmental Area.