Figure 4.

Effects of three APDs on D₁ and D₂ receptor (D₁R and D₂R) expression levels in the PFC (D₁R: (A’,A”); D₂R: (B’,B”)) and NAc (D₁R: (C’,C”); D₂R: (D’,D”)) of female and male rats. Sprague-Dawley rats were treated chronically with Aripiprazole (1.0 mg/kg, t.i.d), Olanzapine (1.0 mg/kg, t.i.d), Risperidone (0.3 mg/kg, t.i.d) or control (vehicle). Data expressed as mean ± SEM. ** p < 0.01 vs. control. The representative bands of Western blot are shown. APD: Antipsychotic drug; NAc: Nucleus Accumbens; PFC: Prefrontal cortex; t.i.d.: Three times daily.