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. 2016 Oct 6;7(10):e2393. doi: 10.1038/cddis.2016.304

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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AAV9-WT-hCASQ2 infection normalizes intracellular calcium dynamics in HO-CMs. (a) Measurement of transient fluorescence amplitude show significantly higher transients in HO-CMs than HO-CASQ2. (b) Representative images of Ca²⁺ sparks represented as an X-Time 3D profile. False colors change with fluorescence intensity. (c, d) Diagrams showing measurements of calcium sparks density and durations. Calcium sparks have higher density and lower duration in HO-CMs, while CASQ2 overexpression re-establishes the phenotype to a behavior compatible with parameters' values measured in the WT cells and HE-CMs. P-values are color coded with the respective sample (*P<0.05; **P<0.01; ***P<0.001). The data are the mean of values registered on CMs derived from two independent iPSC lines in each condition