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. 2016 Oct 27;7(10):e2436. doi: 10.1038/cddis.2016.325

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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miR-203 targets Runx2 and inhibits the β-catenin and ERK pathways. (a) hFOB1.19 cells were transfected with agomiR-203 or antagomiR-203. Western blot analysis of the relative levels of Runx2, β-catenin, p-ERK and ERK protein expression at 48 h. (b) Real-time PCR analysis of the relative levels of miR-203 expression in hFOB1.19 cells transfected with 10 μM agomiR-203, antagomiR-203 or their NCs. (c) Densitometric analysis of Runx2, β-catenin and p-ERK in the hFOB1.19 cells transfected with agomiR-203 or antagomiR-203. (d) Real-time PCR analysis of Runx2, β-catenin (CTNNB1 gene) and ERK (MAPK1 gene) in the hFOB1.19 cells transfected with agomiR-203 or antagomiR-203. The data are representative of three independent experiments. *P<0.01; NS, not significant