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. 2016 Oct 27;7(10):e2436. doi: 10.1038/cddis.2016.325

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Therapeutic overexpression of miR-203 inhibits HO in vivo. (a) The Achilles tendon of the mice was divided at its midpoint with a surgical knife to generate a traumatic HO model. Then the mice were injected weekly at the lesion with agomiR-203, antagomiR-203, or their NCs (PBS was used as the control). Representative micro-CT reconstructed images of HO in the control, agomiR-NC, agomiR-203, antagomiR-NC and antagomiR-203 mice. (b) Quantification of the HO volumes. (c) Total RNA was isolated from the mice HO. The relative miR-203 levels were detected by real-time PCR assays. (d) HO tissues from the mice were decalcified, and the expression of Runx2, β-catenin and p-ERK was detected by immunohistochemistry at week 8. (e) Quantification of Runx2, β-catenin and p-ERK expression. n=10 per group. The data are shown as the means±S.D. *P<0.01