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. 2016 Oct 13;7(10):e2415. doi: 10.1038/cddis.2016.333

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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CDK5 promoted the aggressive behavior and proliferation ability of CRC cells in vitro. (a) Western blotting analyses of CDK5 in specific shRNA-transduced stable HCT116, SW480 cells and Lovo cell with ectopic expression of CDK5. (b and c) Proliferation assay of CCK8 experiments and colony-formation assays were used for detecting the proliferation ability in CDK5 knocked down or overexpression CRC cell lines. (d) Overexpression of CDK5 promoted cell growth of Lovo and silencing endogenous CDK5 inhibited the cell growth of HCT116 as determined by anchorage-independent growth-ability assays. Only cell colonies >0.1 mm in diameter were counted. *P<0.05