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. 2016 Oct 13;7(10):e2415. doi: 10.1038/cddis.2016.333

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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CDK5 promoted metastasis of CRC in vitro and in vivo. (a) Transwell assays were performed to detect the migration and invasion ablilty of CRC cell lines with CDK5 knocked down or overexpressed, respectively. Error bars represent mean±S.D. from three independent experiments. *P<0.05. (b) Representative images of gross specimens and hematoxylin and eosin staining of lung metastatic lesions formed in mice orthotopically implanted with HCT116/Scramble, HCT116/ShCDK5, Lovo/Vector and Lovo/CDK5 cell lines