Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Oct 13;7(10):e2415. doi: 10.1038/cddis.2016.333

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Knocking down CDK5 downregulated a cluster of genes of the ERK5–AP-1 axis. (a and b) Canonical pathway enrichment of whole-genome expression microarray in CDK5 knocked down HCT116 cells was analyzed by IPA. Predicted activation state of each pathway was based on the regulation z-score (Increased: The z-score is ⩾2. IPA predicts that the process or disease will increase. Decreased: The z-score ⩽−2. IPA predicts that the process or disease will decrease). (c and d) Gene interaction network suggested a cluster of genes regulated by transcription factors FOS and JUN (In IPA database, JUN was used to represent transcription factor AP-1). (e) Heat-map analysis showed a cluster of AP-1-dependent genes regulated by CDK5 as indetified by microarray profiling