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. 2016 Oct 27;7(10):e2439. doi: 10.1038/cddis.2016.348

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Enhanced germinal center response in Il2ra^−/−Tg mice. Representative flow cytometry result of (a) follicular helper T cells (PD-1^hiCXCR5⁺ in CD4⁺CD19⁻) and (c) germinal center B cells (GL7⁺CD95⁺ in CD19⁺) and (e) plasma cells (CD19^loB220^-CD138^hi in total cells) in pLN of Il2ra^−/−Tg and littermate control mice. (b) Follicular helper T-cell percentage in CD4⁺ T cells and absolute number in pLN of Il2ra^−/−Tg (n=8), Il2ra^−/− (n=8), Il2ra^+/−Tg (n=8) and Il2ra^+/− (n=8) mice. (d) Germinal center B-cell percentage in B cells and number in pLN of Il2ra^−/−Tg (n=8), Il2ra^−/− (n=7), Il2ra^+/−Tg (n=7) and Il2ra^+/− (n=7) mice. (f) Plasma cell percentage and number in pLN of Il2ra^−/−Tg (n=6), Il2ra^−/− (n=6), Il2ra^+/−Tg (n=6) and Il2ra^+/− (n=6) mice. (g) Serum concentration of IgG1, IgG2a, IgG2b, IgG3 and IgM of Il2ra^−/−Tg (n=7), Il2ra^−/− (n=7), Il2ra^+/−Tg (n=7) and Il2ra^+/− (n=7) mice. Data are shown in mean±S.E.M. *P<0.05, **P<0.01, ***P<0.001. (Student's t test)