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. 2016 Oct 27;7(10):e2439. doi: 10.1038/cddis.2016.348

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Treg cells are skewed to Th1-like stable phenotype in Il2ra^−/−Tg mice. (a) Percentage of CXCR3⁺ Treg cells in thymus and pLN of Il2ra^−/−Tg (n=5), Il2ra^−/− (n=4), Il2ra^+/−Tg (n=4) and Il2ra^+/− (n=5) mice. (b) Percentage of Eomes⁺ Treg cells in thymus and pLN of Il2ra^−/−Tg (n=4), Il2ra^−/− (n=3), Il2ra^+/−Tg (n=3) and Il2ra^+/− (n=6) mice. (c) Representative flow cytometry result of Foxp3 and CXCR3, Eomes expression on CD4⁺CD8⁻ T cells from thymus and pLN of Il2ra^−/−Tg and control mice. (d) IFN-γ secreting ability of thymus and pLN Treg cells from Il2ra^−/−Tg (n=5), Il2ra^−/− (n=4), Il2ra^+/−Tg (n=5) and Il2ra^+/− (n=5) mice. (e) Ly6C expression of thymus and pLN Treg cells from Il2ra^−/−Tg (n=6), Il2ra^−/− (n=6), Il2ra^+/−Tg (n=6) and Il2ra^+/− (n=6) mice. (f) Percentage of Foxp3 TSDR CpG demethylation of thymus and spleen/pLN Treg cells from Il2ra^−/−Tg and Il2ra^+/− mice. Data are shown in mean±S.E.M. *P<0.05, **P<0.01, ***P<0.001. (Student's t test)