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. 2016 Oct 27;7(10):e2439. doi: 10.1038/cddis.2016.348

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Copyright © 2016 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Defective Nrp-1⁺ Treg and follicular regulatory T-cell development in Il2ra^−/−Tg mice. (a) Representative flow cytometry results of Nrp-1 expression on Treg and conventional CD4⁺ T cells from thymus and pLN of Il2ra^−/−Tg and littermate control mice. (b) Nrp-1⁺ percentage of Treg in thymus and pLN from Il2ra^−/−Tg (n=5), Il2ra^−/− (n=5), Il2ra^+/−Tg (n=5) and Il2ra^+/− (n=5) mice. (c) Representative flow cytometry results of PD-1 expression on Treg and conventional CD4⁺ T cells from thymus and pLN of Il2ra^−/−Tg and littermate control mice. (d) PD-1⁺ percentage of Treg in thymus and pLN from Il2ra^−/−Tg (n=5), Il2ra^−/− (n=5), Il2ra^+/−Tg (n=5) and Il2ra^+/− (n=5) mice. (e) Representative flow cytometry result of Tfr in Tfh cells in pLN of Il2ra^−/−Tg and littermate control mice. Percentage of Tfr cells (f) in Tfh cells and (h) in Treg cells in pLN of Il2ra^−/−Tg (n=6), Il2ra^−/− (n=6), Il2ra^+/−Tg (n=6) and Il2ra^+/− (n=6) mice. (g) Nrp-1 and Foxp3 expression of Tfh cells in pLN of Il2ra^−/−Tg and littermate control mice. Data are shown in mean±S.E.M. ***P<0.001. (Student's t test)