Fig. 2.

Representative screenshots of functional elements within CD19⁺ cell genomes generated from the University of California, Santa Cruz genome browser. Red boxes Potential active enhancers, showing signal peak regions in H3K4me1, H3K4me3, and/or H3K27ac. Upper panel LD block of SNP rs10028805. Genes within this block are noted. The LD block contains enhancer regions with multiple potential TFBSs (gray and/or black bars under the TF ChIP-seq track). Lower panel LD block of SNP rs2941509. Similar findings as in Fig. 1a are noted. ChIP data on the H3K4me1, H3K4me3, and H3K27ac enhancers are from the Roadmap Epigenomics project. ChIP-seq chromatin immunoprecipitation sequencing, Chr chromosome, hg19 human genome 19, ENCODE Encyclopedia of Functional DNA Elements