Table 2.
Hip fracture risk factors (demographic and comorbidities) in AD and non-AD cohorts (persons with previous fractures excluded)
| Risk factor | Category | AD cohort | Non-AD cohort | ||||
|---|---|---|---|---|---|---|---|
| IR/ 100 PY | Unadjusted HR (95% CI) |
Adjusted HRa (95% CI) |
IR/ 100 PY | Unadjusted HR HR (95% CI) |
Adjusted HRa
HR (95% CI) |
||
| Age at baseline, increase per year | 1.07 (1.06–1.07) | 1.06 (1.06–1.07) | N.A | 1.12 (1.11–1.12) | 1.12 (1.11–1.13) | ||
| Sex | Men | 2.50 | 1.00 (reference) | 1.00 (reference) | 1.05 | 1.00 (reference) | 1.00 (reference) |
| Women | 1.58 | 0.63 (0.59–0.68) | 0.73 (0.68–0.78) | 0.64 | 0.61 (0.56–0.67) | 0.76 (0.69–0.84) | |
| Highest occupational social class before follow-up | Managerial/professional | 1.83 | 1.00 (reference) | 1.00 (reference) | 0.66 | 1.00 (reference) | N.A |
| Office worker | 2.52 | 1.38 (1.23–1.54) | 1.17 (1.04–1.31) | 0.95 | 1.45 (1.23–1.72) | ||
| Farming/forestry | 2.05 | 1.12 (1.02–1.24) | 0.95 (0.86–1.04) | 0.94 | 1.45 (1.26–1.66) | ||
| Sales/industry/cleaning | 2.15 | 1.18 (1.08–1.27) | 1.04 (0.96–1.13) | 0.96 | 1.47 (1.31–1.66) | ||
| Unknown | 3.27 | 1.79 (1.62–1.99) | 1.19 (1.06–1.32) | 1.48 | 2.30 (1.97–2.68) | ||
| Did not respond | 2.50 | 1.36 (1.00–1.87) | 1.16 (0.85–1.58) | 0.25 | 0.38 (0.25–0.56) | ||
| Hip replacement | No | 1.22 | 1.00 (reference) | 1.00 (reference) | 0.52 | 1.00 (reference) | 1.00 (reference) |
| Yes | 41.83 | 42.0 (39.5–44.6) | 38.8 (36.5–41.2) | 36.47 | 94.3 (86.4–103.0) | 71.2 (65.1–77.9) | |
| Knee replacement | No | 2.14 | 1.00 (reference) | 1.00 (reference) | 0.88 | 1.00 (reference) | 1.00 (reference) |
| Yes | 59.15 | 28.4 (23.4–34.4) | 25.3 (20.8–30.7) | 36.84 | 45.9 (35.9–58.6) | 40.3 (31.5–51.5) | |
| Cardiovascular disease | No | 2.18 | 1.00 (reference) | 1.00 (reference) | 0.83 | 1.00 (reference) | 1.00 (reference) |
| Yes | 2.19 | 1.01 (0.95–1.06) | 0.94 (0.89–1.00) | 0.98 | 1.20 (1.11–1.30) | 0.99 (0.91–1.07) | |
| Stroke | No | 2.18 | 1.00 (reference) | 1.00 (reference) | 0.86 | 1.00 (reference) | 1.00 (reference) |
| Yes | 2.30 | 1.06 (0.96–1.17) | 1.05 (0.95–1.16) | 1.42 | 1.67 (1.47–1.89) | 1.42 (1.26–1.62) | |
| Diabetes | No | 2.19 | 1.00 (reference) | 1.00 (reference) | 0.89 | 1.00 (reference) | 1.00 (reference) |
| Yes | 2.14 | 0.98 (0.90–1.06) | 1.03 (0.95–1.13) | 0.99 | 1.11 (0.98–1.26) | 1.13 (0.99–1.28) | |
| Cancer treatment | No | 2.19 | 1.00 (reference) | 1.00 (reference) | 0.90 | 1.00 (reference) | 1.00 (reference) |
| Yes | 2.06 | 0.94 (0.71–1.24) | 1.01 (0.76–1.34) | 1.31 | 1.44 (1.05–1.98) | 1.67 (1.22–2.30) | |
| Asthma/COPD | No | 2.18 | 1.00 (reference) | 1.00 (reference) | 0.90 | 1.00 (reference) | 1.00 (reference) |
| Yes | 2.24 | 1.02 (0.93–1.13) | 1.03 (0.94–1.14) | 0.95 | 1.05 (0.91–1.21) | 1.07 (0.93–1.23) | |
| Any mental or behavioural disorder | No | 2.09 | 1.00 (reference) | 1.00 (reference) | 0.85 | 1.00 (reference) | 1.00 (reference) |
| Yes | 2.53 | 1.21 (1.14–1.29) | 1.16 (1.09–1.24) | 1.53 | 1.83 (1.63–2.05) | 1.71 (1.52–1.92) | |
aAdjusted for occupational social class