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. 2016 Dec 1;7:181. doi: 10.1186/s13287-016-0439-4

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — DCA/LCA induction of drug exclusion in HCoEpiC. Ability of HCoEpiC cells to exclude Hoechst dye (H33342) was greatly increased following 30-day incubation with DCA or LCA (a). Likewise, the expression of ABCB1 and ABCG2 was also increased in HCoEpiC cells following 18-day exposure to 50 μM LCA (b, c). Controls contained the appropriate vehicle. Data represent the mean ± standard deviation of three separate determinations. **P < 0.01 and ***P <0.001 Statistical significance determined by t test. DCA (deoxycholic acid), LCA (lithocholic acid)