Table 2.

Progressive nature of AGU: mouth, head and face, skin, connective tissue, health and test findings according age

Age in years	Mouth	Head and Face	Skin	Connective tissue	State of health	Test findings, brain MRI
<2	Normal	Macrocephalia, broad mandiple, short and broad nose	Facial erythema	Hernia, planovalgus, clubfoot	Respiratory infections, diarrhoea	Vacuolated cells in all tissues
2–5	Large tongue, broad dental arches, food retention	Generous cheeks, periorbital fullnes	Piezogymic papules in heels, white spots	Tapered fingers, lordosis	Respiratory infections, diarrhoea	Delayed myelination, decreased T2 signal intensity of the thalami
6–9	Gingivitis, oral candida	No change	No change	Bulging abdomen, knock-knees	Benign subcutaneous tumors	Thick and misshapen ribs, vertebral dysplasia
10–15	Gingival overgrowts	No change	Facial seborrhoea	Broad and low ball of foot	Arthritis rheumatoides	Decreased T2 pulvinar signal intensity, mild cerebral atrophy
16–19	Edemic cheeks, cross bite	No change	Angiokeratoma	Thoracic deformity	Psychotic periods, epilepsy	Neutropenia, thrombopenia, mild cerebellar atrophy
20–24	No change	Coarsening facial feature	Facial angiofibromas	Childish appearance	Restless sleep, confusion periods	Evident cerebral and cerebellar atrophy
25–34	No change	Thick eyebrows	Facial rosacea	Poor carriage	Epilepsy	–
35–44	Loss of teeth and loss of gingical overgrowts	Thick and broad/full lips	Loose skin	Muscle atrophy and hypotony	Bursitis, osteoporosis, orofacial	Attenuation in EEG
45+	Drooling	Microcephalia	Angiofibromas and rosacea increse	Contractures in fingers and elbows	Abscesses, fistula of skin, diarrhoea, anaemia, hearth insufficiency, p	Progression of cerebral and cerebellar atrophy