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. 2016 Dec 1;48:95. doi: 10.1186/s12711-016-0274-1

Table 4.

Phenotypic variance explained (h2) in 2287 validation animals for protein yield (PY), somatic cell score (SCS) and interval first –last insemination (IFL)

Trait Selection criteria ISQ HD 50k ISQ HD 50k ISQ HD 50k
Selected set of variants
(GRM)
Complementary set of variants (GRMc) Sum of GRM and GRMc
PY All variants 0.83 0.98 0.70 0.00 0.12 0.83 0.98 0.82
−log10(p) > 3 0.19 0.15 0.09 0.61 0.65 0.73 0.80 0.80 0.82
−log10(p) > 5 0.10 0.04 0.03 0.74 0.79 0.80 0.84 0.83 0.83
COJO3 0.11 0.70 0.81
COJO5 0.10 0.71 0.81
COJO5LD 0.08 0.73 0.82
COJO#100 0.09 0.72 0.82
SCS All variants 0.87 0.87 0.48 0.00 0.38 0.87 0.87 0.86
−log10(p) > 3 0.22 0.15 0.05 0.60 0.68 0.80 0.82 0.83 0.85
−log10(p) > 5 0.24 0.03 0.01 0.64 0.84 0.85 0.88 0.87 0.86
COJO3 0.14 0.68 0.81
COJO5 0.14 0.66 0.80
COJO5LD 0.05 0.79 0.84
COJO#100 0.08 0.76 0.83
IFL All variants 0.72 0.85 0.50 0.00 0.21 0.72 0.85 0.70
−log10(p) > 3 0.20 0.12 0.05 0.51 0.57 0.64 0.70 0.69 0.69
−log10(p) > 5 0.11 0.03 0.03 0.63 0.69 0.70 0.73 0.72 0.72
COJO3 0.11 0.57 0.67
COJO5 0.12 0.57 0.69
COJO5LD 0.07 0.64 0.71
COJO#100 0.08 0.64 0.71

COJO analysis with −log10(p) > 3 (COJO3) or −log10(p) > 5 (COJO5); ISQ are all imputed sequence variants, HD and 50k are the SNPs on the common HD and 50k panels

Variances are estimated fitting GRM and GRMc together in one model where GRM were based on the selected set of variants and GRMc on the complementary variants. Set of variants that were selected using GWAS results on 3469 discovery animals