Table 2.
Interaction analyses of the PNPLA3 rs738409 polymorphism and behavioral factors on childhood NAFLD
| Percentage of NAFLD children (number of NAFLD cases/number of the subgroup) | |||||||
|---|---|---|---|---|---|---|---|
| CC | GC | GG | ORa (95% CI) | P a | ORb (95% CI) | P b | |
| Total | 15.1 (60/398) | 15.0 (74/492) | 20.4 (28/137) | 1.57 (1.15–2.16) | 0.005 | ||
| Physical Activity (PA) | |||||||
| PA ≥ 1 h/d | 16.2 (31/191) | 16.0 (38/237) | 11.1 (7/63) | 1.02 (0.63–1.66) | 0.923 | 3.13 (1.57–6.24) | 0.001 |
| PA < 1 h/d | 11.9 (19/160) | 14.7 (31/211) | 31.3 (20/64) | 3.05 (1.82–5.12) | <0.001 | ||
| Sedentary Behavior (SB) | |||||||
| SB < 2 h/d | 14.2 (32/226) | 9.8 (27/276) | 19.5 (16/82) | 1.22 (0.80–1.87) | 0.363 | 2.47 (1.25–4.91) | 0.010 |
| SB ≥ 2 h/d | 14.4 (18/125) | 24.4 (42/172) | 24.4 (11/45) | 3.41 (1.88–6.18) | <0.001 | ||
| PA and SB | |||||||
| PA ≥ 1 h/d & SB < 2 h/d | 17.2 (22/128) | 9.5 (14/147) | 7.3 (3/41) | 0.50 (0.26–0.96) | 0.039 | 6.11 (2.79–13.37) | <0.001 |
| PA < 1 h/d or SB ≥ 2 h/d | 12.6 (28/223) | 18.3 (55/301) | 27.9 (24/86) | 3.17 (2.02–4.96) | <0.001 | ||
NAFLD Non-Alcoholic Fatty Liver Disease, PNPLA3 The patatin like phospholipase containing domain 3 gene, PA Physical Activity, SB Sedentary Behavior
a: the P value of rs738409 in logistic model conducted in each behavioral level, including age, gender, BMI and rs738409 as independent variables
b: the P value of rs738409 × behavior in logistic model conducted for each behavior, including age, gender, BMI, rs738409, behavior, rs738409 × behavior as independent variables