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. 2016 Sep 15;20(12):2374–2383. doi: 10.1111/jcmm.12931

Figure 4.

Figure 4

CRP activated the expression of nuclear HNF1α protein but not SREBP2. (A) (B) Western blot analyses of the transcription factors of PCSK9 including HNF1α and SREBPs in HepG2 cells. (C) (D) Western blot analyses of the expression of HNF1α after the pre‐treatment with SB203580 (10 μM) for 1 hr and then incubated with CRP (10 μg/ml) for 24 hrs. CRP, C‐reactive protein; PCSK9, pro‐protein convertase subtilisin/kexin type 9; HNF, hepatocyte nuclear factor; SREBP, sterol responsive element‐binding protein.