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. 2016 Oct 17;594(23):7105–7126. doi: 10.1113/JP272979

Figure 3. Effects of age and frailty on heart rate and sinoatrial node function in anaesthetized mice .

Figure 3

A, representative ECG recordings during programmed electrical stimulation in a young mouse and an aged mouse. Sinoatrial node recovery time (SNRT) was measured as described in the Methods. B, summary of differences in HR between young and aged mice. C, summary of differences in corrected SNRT (cSNRT) between young and aged mice. Data in B and C analysed by Mann–Whitney rank sum test; n = 29 young and 34 aged mice. D, linear regression analysis of HR as a function of FI for the same mice as used in B. For this and all subsequent linear regression analysis plots the young mice are represented by black circles and the aged mice are represented by red circles. E, linear regression analysis of cSNRT as a function of FI for the same mice as used in C. HR and cSNRT were graded by FI; for D and E, n = 63 mice; correlation coefficients obtained using Pearson's correlation.