Figure 5. Parameters and initial conditions are placed in their own components, here for each high level biological component .

Each has their own parameter set, but the separation allows for parameters to come from other sources too. Shear_Stress_to_IP₃ can run using its own parameters; however, when linked with other modules (such as Calcium_Handling) it may be more appropriate for some parameters to come from that source instead. Following Principle (6) allows such ‘parameter collisions’ to be resolved by the model builder.