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. 2016 Nov 23;16(11):1909. doi: 10.3390/s16111909

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Confocal microscopy imaging of CTC cells mixed with bloods and NIF-EpCAM/muc1 ALB probes. Either 5 pmol NIF-EpCAM ALB or 10 pmol NIF-muc1 ALB was mixed with isolated-bloods two weeks after caerulein injection in Panc02-implanted mice (A). Fluorescence signals two weeks after caerulein treatment were significantly enhanced compared to those of the untreated caerulein in Panc02-implanted group. Positive cell numbers of QD-EpCAM/muc1 ALB on CTC cells in bloods after caerulein treatment (B). Data are represented as mean ± standard deviations of triplicate samples (** p < 0.005). Quantitative positive cells showed a higher fluorescent positive cells in blood with the caerulein-treated Panc02 cells than in mice without caerulein treatment (control) and normal mice, ** p < 0.005.