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Hypothetical model for Sit4-mediated control of Hxk2 phosphorylation. The phosphorylation (red dot) status of Hxk2 controls its subcellular localization and is regulated indirectly via the ceramide-activated phosphatase Sit4, possibly through Reg1-Glc7 or Tda1. As an important regulator and effector of sphingolipid metabolism, Sch9 is likely involved through modulation of Sit4 activity. Dashed lines indicate putative connections. PHS, phytosphingosine.
