Table 1.

TRF2- and TRF2-S-associated proteins and nucleic acids. Top, molecules (proteins, DNA, RNA) that associate with TRF2 (column 1), domain of TRF2 implicated (column 2), influence of these interactions on TRF2 function (column 3), and bibliography describing these functions (column 4). Bottom, molecules (proteins and RNAs) that associate with TRF2-S (column 1), domain of TRF2-S implicated (column 2), influence of these interactions on TRF2-S function (column 3), and bibliography describing these functions (column 4).

TRF2 binding partners	TRF2 domain	TRF2 function	References
Duplex telomeric DNA	Myb	TRF2 protects telomeres from end-to-end fusions	64
DNA replication fork	GAR	TRF2 promotes telomere replication	65
TERRA RNA	GAR	TRF2 recruits ORC and TERRA to telomeres	32
PARP1, poly(ADP-ribose) polymerase	GAR	TRF2 recruits PARP1 to damaged telomeres	66
PRMT1, protein methyltransferase	GAR	Arginines in TRF2 GAR domain are methylated	36
OPC1 (origin recognition complex)	GAR	TRF2 is recruited to telomeres at S-phase	32
REST (neuron-restrictive transcription repressor)	TRFH	TRF2 prevents REST degradation	46
hREST4 (REST splicing isoform)	TRFH-F120	TRF2 prevents hREST4 degradation	49
RAP1 (repressor/activator1)	TRFH-F120	TRF2 forms shelterin complex	67
SLX4 (endonuclease)	TRFH-F120	TRF2 assembles with multiple endonucleases	68
Apollo (nuclease)	TRFH-F120	TRF2 protects telomeres in S phase	38
RTEL1 (helicase)	TRFH	TRF2 unwinds telomere t-loops in S phase	11
WRN (RecQ helicase)	N/A	TRF2 lacking GAR domain forms telomeric circles, telomere recombination, and senescence	69
ATM (sensor of double-stranded DNA damage)	N/A	TRF2 inhibits ATM activation at telomeres	14
MRE11 (nuclease)	N/A	TRF2 prevents assembly of TERRA-LSD1-MRE11 at damaged telomeres	31
TRF2-S binding partners	TRF2-S domain	TRF2-S function	References
G-rich mRNAs	GAR	TRF2-S binds to and facilitates neuron mRNA trafficking	50
FMRP	GAR	TRF2-S binding to mRNA is suppressed by FMRP	50
REST	TRFH	TRF2-S sequesters REST in the cytoplasm	17