Table 1.
Haploinsufficient gene set.
| Gene | Gene E or V | % Deviation from control mean | % Deviation from control median | GO slim term biological process | Gene function |
|---|---|---|---|---|---|
| SPAC212.05c | V | 0 | 0 | control | Pseudogene |
| dea2 | E | +31.94 | +29.28 | GO:0055086-nucleobase-containing small molecule metabolic process | adenine deaminase |
| nup184 | V | +23.46 | +23.43 | GO:0006913 – nucleocytoplasmic transport GO:0006605 – protein targeting | nucleoporin |
| nsp1 | E | +19.29 | +18.17 | GO:0006913 – nucleocytoplasmic transport GO:0042254 – ribosome biogenesis | nucleoporin |
| nup97 | E | +18.92 | +16.86 | GO:0006913 – nucleocytoplasmic transport | nucleoporin Nic96 homolog |
| cdc13 | E | +16.78 | +16.72 | GO:0007346 – regulation of mitotic cell cycle | G2/M B-type cyclin |
| nup186 | E | +15.82 | +13.34 | GO:0006913 – nucleocytoplasmic transport | nucleoporin Nup186 |
| cdc25 | E | +15.55 | +15.85 | GO:0007346 – regulation of mitotic cell cycle | M phase inducer tyrosine phosphatase |
| cdc2 | E | +14.43 | +12.31 | GO:0007346 – regulation of mitotic cell cycle | cyclin-dependent protein kinase |
| cdr1 | V | +11.63 | +11.80 | GO:0007346 – regulation of mitotic cell cycle | NIM1 family serine/threonine protein kinase |
| sal3 | V | +10.81 | +10.87 | GO:0006913 – nucleocytoplasmic transport | β importin |
| nup45 | E | +8.80 | +8.93 | GO:0006913 – nucleocytoplasmic transport | nucleoporin |
| cpc2 | V | +8.78 | +8.72 | GO:0002181 – cytoplasmic translation GO:0007010 – cytoskeleton organization | RACK1 ortholog |
| nup189 | E | +8.74 | +8.47 | GO:0006913 – nucleocytoplasmic transport | nucleoporin Nup98 and Nup96 |
| ppa2 | V | −9.10 | −8.94 | GO:0007346 – regulation of mitotic cell cycle | serine/threonine protein phosphatase |
| suc1 | E | −10.86 | −10.90 | GO:0000079 – regulation of cyclin- dependent protein serine/threonine kinase activity | cyclin-dependent protein kinase regulatory subunit |
| pom1 | V | −11.06 | −11.15 | GO:0007010 – cytoskeleton organization GO:0007346 – regulation of mitotic cell cycle | DYRK family protein kinase |
| wee1 | V | −16.50 | −16.75 | GO:0007346 – regulation of mitotic cell cycle | M phase inhibitor protein kinase |
Heterozygous gene deletion diploid strains that divide at greater than 8% longer or shorter than the control strain for both mean cell length and median cell length. E= essential gene, V= non-essential gene.