Table 3.
Additive Genetic Heritability of CAMP phenotypes. These are computed using the GCTA program 46, which does a computation based on the GRM to estimate the heritability explained by SNPs in a genome‐wide SNP sample in the cohort. For the 13 phenotypes, we have computed the heritability contained in the SNPs of the CAMP GWAS with and without adjustment for genotype principal components. Each heritability is listed with standard error in parentheses, where * indicates heritability significantly different from 0 at p < 0.05, and ** is significantly different from 0 at p < 0.01. NA: heritability estimate did not converge. Accuracy using the GRM method is listed in AUC, with + indicating prediction significantly greater than random (p < 0.05, permutation test)
| All SNPs (±Std) | All SNPs+PCs (±Std) | GRM (AUC, %) | |
|---|---|---|---|
| AHR | NA | .45 (.29) | 52.3 |
| IGE | .42 (.24)** | .53 (.27)* | 58.0+ |
| EOS | .38 (.26) | .29 (.32) | 54.1 |
| Pre‐FEV1 | .71 (.22)** | .81 (.22)** | 58.1+ |
| Post‐FEV1 | .65 (.24)** | .83 (.22)** | 56.1+ |
| BDR | .52 (.25) | .67 (.24)* | 53.6 |
| SRE | .01 (.05) | .00 (.42) | 51.1 |
| NG | .54 (.22)** | .47 (.27) | 59.6+ |
| NG‐ED | .41 (.24) | .55 (.23)* | 56.7+ |
| RG | .38 (.25) | .49 (.26) | 56.8+ |
| RG‐ED | .25 (.20) | .17 (.27) | 56 |
| ED ALL | .25 (.20) | .22 (.28) | 54.7 |
| RG ALL | .94 (.19)** | .95 (.19)** | 61.7+ |