Table 7.
Effect of age and exercise training on plasma markers of oxidative stress, antioxidants and inflammation
| Marker | Y‐ApoE‐UT | O‐ApoE‐UT | O‐ApoE‐ExT | O‐C57‐UT | O‐C57‐ExT |
|---|---|---|---|---|---|
| AOPP (μmol l−1) | 202.6 ± 9.1 | 152.4 ± 11.8* | 131.0 ± 10.7* | 15.3 ± 2.6‡ | 13.3 ± 2.7‡ |
| GPX (μmol l−1 min−1) | 123.0 ± 17.7 | 113.4 ± 14.5 | 102.4 ± 13.7 | 109.3 ± 15.2 | 227.0 ± 62.8† |
| Nitrotyrosine (nmol l−1) | 25.6 ± 3.8 | 50.6 ± 11.0* | 66.4 ± 8.9* | 36.4 ± 4.0‡ | 26.4 ± 5.2‡ |
| NOx (μmol l−1) | 22.3 ± 1.3 | 22.6 ± 1.0 | 27.3 ± 1.1*† | 28.3 ± 2.4‡ | 35.7 ± 3.2*†‡ |
| SOD (μmol ml−1 min−1) | 37.1 ± 1.0 | 32.3 ± 1.4* | 36.7 ± 1.2 | 27.3 ± 1.8 | 33.3 ± 3.1† |
| TNFα (pg ml−1) | 82.3 ± 7.9 | 42.3 ± 8.9* | 40.8 ± 6.7* | 46.3 ± 5.6 | 72.4 ± 16.4† |
| IL‐1β (pg ml−1) | 157.6 ± 14.7 | 118.2 ± 6.8* | 114.2 ± 8.2* | 111.5 ± 22.7 | 105.4 ± 12.8 |
Abbreviations: AOPP, protein oxidation; FRAP, ferric reducing antioxidant power; GPX and SOD, antioxidant enzymes activities; IL‐1β, interleukin‐1β; nitrotyrosine, protein nitration; NOx, nitric oxide metabolism (nitrites plus nitrates); and TNFα, tumour necrosis factor‐α. Groups are as in Table 2. *Significantly different (P < 0.05) from young. †Significantly different (P < 0.05) from corresponding untrained. ‡Significantly different (P < 0.05) from corresponding ApoE−/−.