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. 2016 Nov 1;17(6):1657–1670. doi: 10.1016/j.celrep.2016.10.024

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© 2016 The Author(s)

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effects of Chronic and Acute Treatment of Sulfolobus solfataricus with Hydroxyurea

(A) Serial dilutions of S. solfataricus cells were plated on media containing the indicated concentrations of HU.

(B) Viable cell counts measured by plating efficiency following the indicated doses of HU; assays were performed in triplicates and the bars indicate the mean; error bars are SDs. Results are expressed relative to untreated cells (set at 100%).

(C) Flow cytometry profiles of cells following the indicated treatment and recovery times.

(D) Agarose gel analysis of the integrity of genomic DNA isolated from cells following exposure to 5 or 10 mM HU for 4 or 7 hr.

(E) Representative micrograph showing phase contrast and fluorescence imaging of treated or untreated cells. DNA was stained with DAPI and membranes with FM-464.