Table 1.
Transcripts Showing Significant (p < 0.05) Alterations in Level following Treatment with 5 mM Hydroxyurea for 4 hr
| Genes | Description | Fold Change (log2) | p Value |
|---|---|---|---|
| SSO2292∗ | Amino acid transport | −4.5 | 0.006 |
| SSO6264∗ | Purine biosynthesis operon | −4.2 | 0.024 |
| SSO0626∗ | 5-Aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase—and linked genes | −4 | 0.024 |
| SSO3189∗ | Amino acid transporter | −3.9 | 0.019 |
| SSO2017+8 | Enoyl-CoA hydratase, 1,2-phenylacetyl-CoA epoxidase—detoxification—has di-iron center SSO2018 may have role in benzoate catabolism | 3.3 | 0.049 |
| SSO1817 | Thiosulfate sulfur transferase | 3.4 | 0.047 |
| SSO2908:2909: 2911 | Uroporphyrin-III C-methyltransferase (sirohemesynthase) (cysG): sulfite reductase hemoprotein beta component(cysI): 3′-phosphoadenosine 5′-phosphosulfatesulfotransferase (PAPS reductase) (cysH)—4Fe⋅4S cluster-containing | 3.4 | 0.046 |
| SSO3059 | Maltose transporter, permease | 3.4 | 0.046 |
| SSO3058 | Maltose transporter, permease | 3.6 | 0.036 |
| SSO2881 | FeS-containing radical SAM enzyme | 3.6 | 0.036 |
| SSO2858 and 2860 | Selenium binding protein (possible role in redox modulation) | 3.7 | 0.036 |
| SSO2912: 2913:2914 | Sulfate adenylyltransferase (sat): hypothetical: TauE (sulfite or taurine exporter) | 3.6 | 0.032 |
| SSO1591 | Symporter | 3.6 | 0.036 |
| SSO2019–2022 | Benzoate catabolism | 3.8 | 0.047 |
| SSO2966 | Hypothetical | 3.8 | 0.046 |
| SSO1369 | Thiamine pyrophosphate-dependent dehydrogenase | 3.9 | 0.036 |
| SSO3045–3048 | Oligopeptide transport | 4 | 0.048 |
| SSO2671 | Oligopeptide ABC transporter | 4 | 0.032 |
| SSO2976 | Hypothetical | 4.2 | 0.024 |
| SSO1593 | Major facilitator superfamily transporter for benzoate | 4.4 | 0.006 |
| SSO1102 | Hypothetical transcriptional regulator—possible metal binder | 4.5 | 0.014 |
| SSO1816 | FeS-containing protein—ferredoxin-like | 4.5 | 0.014 |
| SSO3055 | Maltose transporter, ABC | 4.5 | 0.0061 |
| SSO2089 | Ten-A/THI-4—adjacent to protease, so more like TenA? | 4.5 | 0.024 |
| SSO1741+2 | DoxAD thiosulfate:quinone oxidoreductase | 4.7 | 0.0075 |
| SSO1324 | Thiamine biosynthesis—4Fe⋅4S-containing | 4.7 | 0.0047 |
Genes showing reduced expression after HU treatment are highlighted with an asterisk (∗).