Table 2.
Characteristics of subjects with and without SBI and WMH in the upper quartile (WMHV-Q4)
| SBI (−) (N=816) | SBI (+) (N=138) | P | WMHV-Q1-3 (N=716) | WMHV-Q4 (N=238) | P | |
|---|---|---|---|---|---|---|
| Age (years) | 70.9 ± 9.1 | 76.1 ± 8.8 | <0.001 | 69.6 ± 8.7 | 77.7 ± 8.1 | <0.001 |
| Male, n (%) | 288 (35.3) | 63 (45.7) | 0.020 | 268 (37.4) | 83 (34.9) | 0.479 |
| Race-Ethnicity | ||||||
| White, n (%) | 111 (13.6) | 23 (16.7) | 106 (14.8) | 28 (11.8) | ||
| Hispanic, n (%) | 568 (69.6) | 82 (59.4) | 0.114 | 503 (70.3) | 147 (61.8) | 0.001 |
| Black, n (%) | 120 (14.7) | 29 (21.0) | 93 (13.0) | 56 (23.5) | ||
| Other, n (%) | 17 (2.1) | 4 (2.4) | 14 (2.0) | 7 (2.9) | ||
| Body mass index, kg/m2 | 28.4 ± 4.9 | 27.8 ± 4.6 | 0.159 | 28.5 ± 4.9 | 27.6 ± 4.8 | 0.012 |
| Hypertension, n (%) | 634 (77.7) | 124 (89.9) | 0.001 | 542 (75.7) | 216 (90.8) | <0.001 |
| Hypercholesterolemia, n (%) | 554 (67.9) | 96 (69.6) | 0.697 | 490 (68.4) | 160 (67.2) | 0.729 |
| Diabetes mellitus, n (%) | 232 (28.4) | 51 (37.0) | 0.043 | 204 (28.5) | 79 (33.2) | 0.169 |
| Coronary artery disease, n (%) | 45 (5.5) | 12 (8.7) | 0.145 | 40 (5.6) | 17 (7.1) | 0.380 |
| History of MI, n (%) | 36 (4.4) | 9 (6.5) | 0.280 | 32 (4.5) | 13 (5.5) | 0.531 |
| History of AF, n (%) | 41 (5.0) | 19 (13.8) | <0.001 | 35 (4.9) | 25 (10.5) | 0.002 |
| Smoking history, n (%) | 429 (52.6) | 74 (53.6) | 0.819 | 372 (52.0) | 131 (55.0) | 0.409 |
| Hypertension medication, n (%) | 571 (70.0) | 119 (86.2) | <0.001 | 489 (68.3) | 201 (84.5) | <0.001 |
| Aortic plaque thickness (mm) | 1.9 ± 1.5 | 2.3 ± 1.4 | 0.007 | 1.8 ± 1.4 | 2.4 ± 1.4 | <0.001 |
SBI=silent brain infarct
WMHV=white matter hyperintensity volume
MI=myocardial infarction
AF=atrial fibrillation