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. Author manuscript; available in PMC: 2017 Nov 23.
Published in final edited form as: Cell Syst. 2016 Oct 27;3(5):444–455.e2. doi: 10.1016/j.cels.2016.10.002

Figure 5.

Figure 5

Results for 4-node models. Left column represents idealized models, for which the target responses are shown with a black dashed line, node A in red, node B in orange, node C in green, and node D in blue. Right column represents models fit to experimental yeast PRS data. Hill function fits to the data (target functions) are shown with dashed lines and model fits are shown with solid lines. Node GPCR is shown in red, G-protein in orange, Fus3 in green, and PRM1-YFP in blue. (A) and (F) show results for linear topologies with non-cooperative reactions, (B) and (G) show results for linear topologies with cooperative reactions, (C) and (H) show results for topologies constructed with positive feedforward loops that skip over intermediate nodes, (D) and (I) show results for push-pull mechanisms, (E) shows a pull arrow that skips intermediate nodes, and (J) shows push-pull mechanisms with cooperative reactions. The insets are analogous to those shown in Figure 3.