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(A) Schematic of the TLR domain architecture and activation mechanism. The indicated mechanism was adopted from the TLR3 activation model. (B) Proposed mechanisms by which TLR7 recognizes self-RNAs. TLR7 was shown to be activated by the U1 snRNA or Alu elements upon entry into the endosome, which is mediated by autoantibodies against U1 snRNP and Ro60, or Fc receptors.
