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. 2016 Nov 29;87(22):2324–2332. doi: 10.1212/WNL.0000000000003391

Figure 1. Western blot analysis of Escherichia coli K99 pili protein and Gram-negative bacterial lipopolysaccharide (LPS) in human brains.

Figure 1

(A) Western blot analysis of E coli K99 pili protein in gray matter (GM). E coli K99 was detected in 9 out of 13 Alzheimer disease (AD) cases and 1 out of 10 control (C) cases. (B) Western blot analysis of E coli K99 pili protein in white matter (WM). E coli K99 was detected in 10 out of 13 AD cases and 4 out of 10 control cases. (C) Quantification of E coli K99 protein. E coli K99 protein levels in AD brains were greater than in control aged brains in both GM (*p < 0.05) and WM (**p < 0.01). (D) Western blot analysis of Gram-negative bacterial LPS. A total of 3/3 AD GM, 3/3 AD WM, and 0/3 control GM showed LPS. Error bars are standard errors of the mean. β-actin was used as a loading control.