Table 4. Patient factors and cardiotoxicity.
| Variable | cAC group | Control group | Univariate association | |||
|---|---|---|---|---|---|---|
| Mean (SD) | % | Mean (SD) | % | OR (95% CI) | P value | |
| Age | 48.7 (7.6) | 48.2 (9.2) | 1.06 (0.72–1.55)* | 0.77 | ||
| Age≥60 years | 2.9% | 13.7% | 0.19 (0.00–1.31) | 0.13 | ||
| Height (m) | 1.67(0.07) | 1.63 (0.06) | 1.70 (1.14–2.52)* | 0.008 | ||
| Weight† (kg) | 71.1 (14.5) | 65.1 (11.2) | 1.60 (1.12–2.30)* | 0.01 | ||
| BSA (m2)† | 1.80 (0.18) | 1.70 (0.15) | 1.78 (1.21–2.61)* | 0.003 | ||
| BSA >2.00 (m2) | 14.7% | 4.6% | 3.59 (1.02–12.58) | 0.046 | ||
| BMI† (kg/m2) | 25.6 (4.9) | 24.5 (4.0) | 1.31 (0.90–1.90)* | 0.16 | ||
| BMI≥30 kg/m2 | 20.6% | 13.0% | 1.74 (0.66–4.61) | 0.27 | ||
| Body Fat (%)‡ | 34.8 (7.1) | 31.7 (7.6) | 1.51 (0.97–2.36)* | 0.07 | ||
| Body Fat ≥ 31%¶ | 76.9% | 50.0% | 3.26 (1.20–8.86) | 0.02 | ||
| eGFR (ml/min/1.73m2) | 82.6 (14.0) | 87.5 (15.6) | 0.72 (0.48–1.06)* | 0.10 | ||
| Diabetes | 0.0% | 0.8% | 1.00 | |||
| Diagnosed Hypertension | 2.9% | 1.5% | 0.50 | |||
| Systolic BP (mmHg) | 121.4(17.8) | 116.5 (14.6) | 1.36 (0.94–1.97)* | 0.10 | ||
| Diastolic BP (mmHg) | 73.7 (13.1) | 71.2 (9.4) | 1.27 (0.87–1.86)* | 0.21 | ||
| BP ≥140/90mmHg | 23.5% | 7.7% | 3.69 (1.33–10.26) | 0.01 | ||
| BP <100/60mmHg | 8.8% | 18.5% | 0.43 (0.08–1.56) | 0.27 | ||
*Odds ratios are for a 1 SD increase.
†Data log transformed, geometric means (approximate SDs). Blood pressure (BP) measured in 164 women (163 at enrolment, 143 with CMR)
‡Measurements available for 118 subjects
¶Best discriminator value defined by receiver operator curve (ROC) analysis.