Table 4. Criterion (cut-off*) values and coordinates of the ROC curves of 3MS and major cognitive domains by a detailed neuropsychological test battery.
| Criterion of 3MS | Sensitivity (95%CI) | Specificity (95%CI) | AUC | Youden Index |
|---|---|---|---|---|
| Executive dysfunction | ||||
| ≤81 | 61.59(52.9–69.7) | 85.63(81.3–89.2) | 0.50 | |
| ≤82 | 67.39(58.9–75.1) | 82.57(78.0–86.5) | 0.742 | |
| ≤83 | 71.01(62.7–78.4) | 78.29(73.4–82.6) | ||
| Immediate memory impairment | ||||
| ≤87 | 61.02(55.4–66.5) | 71.34(63.8–78.1) | 0.34 | |
| ≤88 | 65.50(59.9–70.8) | 68.90(61.2–75.9) | 0.662 | |
| ≤89 | 69.01(63.6–74.1) | 64.02(56.2–71.4) | ||
| Delayed memory impairment | ||||
| ≤81 | 61.46(51.0–71.2) | 80.82(75.8–84.3) | 0.42 | |
| ≤82 | 65.62(55.2–75.0) | 76.39(71.7–80.7) | 0.753 | |
| ≤83 | 68.75(58.5–77.8) | 71.94(67.0–76.5) | ||
| Language ability impairment | ||||
| ≤79 | 54.05(42.1–65.7) | 79.26(75.0–83.1) | 0.35 | |
| ≤80 | 56.76(44.7–68.2) | 77.78(73.4–81.7) | 0.717 | |
| ≤81 | 58.11(46.1–69.5) | 75.56(71.1–79.7) | ||
| Visuospatial ability impairment | ||||
| ≤88 | 67.57(61.0–73.7) | 57.56(51.0–63.9) | 0.26 | |
| ≤89 | 72.07(65.7–77.9) | 53.78(47.2–60.2) | 0.672 | |
| ≤90 | 74.77(68.5–80.3) | 48.83(41.8–54.9) | ||
*Optimal cut-off score based on maximal sensitivity and specificity using the receiver operating characteristic (ROC) analysis.
Abbreviation: AUC, area under the curve.