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. 2016 Dec 2;11(12):e0166814. doi: 10.1371/journal.pone.0166814

Table 1. Biologic Functions of Proteins Encoded by Plasmodium falciparum Liver Stage Parasite Genes in Microarray Studies That Are Regulated by γ-Irradiation.

Protein, by Biological Function Gene(s) Day 3 Day 6
Cell Cycle
G10 protein PF3D7_0522800 2.3
Chromatin
histone acetyltransferase PF3D7_0416400 8.3
SET domain protein PF3D7_0629700 6.7
histone deacetylase PF3D7_1472200 2.5
Cytoskeleton
probable protein, unknown function PF3D7_1428400 6.4 6.6
conserved Plasmodium protein, unknown function PF3D7_0529000 4.5 2.9
conserved Plasmodium protein, unknown function PF3D7_0305200 3.6
mitotic-spindle organizing protein 1 PF3D7_1339800 -2.7
conserved Plasmodium protein, unknown function PF3D7_1425500 -2.3
tubulin—tyrosine ligase PF3D7_1009700 -2.3
DNA binding
conserved Plasmodium protein, unknown function PF3D7_1442700 -3.5
DNA repair
DNA mismatch repair protein MSH2 PF3D7_1427500 4.6
conserved protein, unknown function

  • PF3D7_1202100.1

  • PF3D7_1202100.2

 6.4
DNA-3-methyladenine glycosylase PF3D7_1467100 -2.1
DNA repair; RNA
conserved Plasmodium protein, unknown function PF3D7_1333900 15.3
DNA Replication
DNA replication licensing factor MCM6 (MCM6) PF3D7_1355100 -2.6
Metabolism
glycine cleavage T protein PF3D7_1365500 3.0
riboflavin kinase / FAD synthase family protein PF3D7_1359100 -2.5
Metabolism (Lipid)
lysophospholipase PF3D7_1476800 2.6
Metabolism (Nucleotide)
aspartate carbamoyltransferase (ATCase) PF3D7_1344800 10.4
Nuclear envelop
conserved Plasmodium protein, unknown function PF3D7_1446500 -2.5
Protein folding (FeS assembly)
iron-sulfur assembly protein PF3D7_0207200 5.5
Protein folding/Stress response
DnaJ protein PF3D7_1126300 8.4 9.4
heat shock protein 101,chaperone protein ClpB2 (HSP101) PF3D7_1116800 3.6 7.6
DnaJ protein PF3D7_1401100 2.1
exported protein family 1 (EPF1) PF3D7_1101800 -2.4
conserved Plasmodium protein, unknown function PF3D7_1448700 -2.5
conserved Plasmodium protein, unknown function PF3D7_1037900 2.4
Protein processing
stromal-processing peptidase PF3D7_1440200 -2.3
serine repeat antigen 3 (SERA3) PF3D7_0207800 6.3
methionine aminopeptidase 1a PF3D7_0527300 4.7
Protein processing/Autophagy
cysteine protease ATG4 PF3D7_1417300 2.4
Protein processing; Surface/exported protein
rhomboid protease ROM3 (ROM3) PF3D7_0828000 4.5
RNA
RAP protein PF3D7_0526000 5.3
RAP protein PF3D7_1470600 2.2
RAP protein PF3D7_1453600 10.5 4.2
PfMNL-3 mitoNEET-like iron-sulfur protein PF3D7_1022900 4.5
large subunit rRNA processing RRM protein PF3D7_1020000 4.1
RNA-binding protein

  • PF3D7_1002400.1

  • PF3D7_1002400.2

 14.2 4.5
RNA-binding protein PF3D7_0606100 3.4 3.7
zinc finger protein PF3D7_1358600 2.2
ATP dependent DEAD-box helicase PF3D7_0623700 -2.2
Ran-binding protein PF3D7_1353400 -2.6
mRNA cleavage factor-like protein PFA_0450c -2.2
RNA metabolism
DEAD box helicase PF3D7_1307300 5.9
cell cycle control protein PF3D7_1238300 12.4
exosome complex exonuclease RRP44 (DIS3) PF3D7_1359300 6.2
early transcribed membrane protein 14.2 (ETRAMP14.2) PF3D7_1476100 2.3 7.3
conserved Plasmodium protein, unknown function PF3D7_0930100 -2.1
conserved Plasmodium protein, unknown function PF3D7_0921100 -2.2
conserved Plasmodium protein, unknown function PF3D7_0412200 -2.8
conserved Plasmodium protein, unknown function PF3D7_1411500 -3.1
RNA metabolism; chromatin
DNA/RNA-binding protein Alba 3 (ALBA3) PF3D7_1006200 6.7
RNA;chromatin
endonuclease/exonuclease/phosphatase family protein PF3D7_0319200 4.1
RNA;Ubiquitin
CCR4-NOT transcription complex subunit 4 PF3D7_1235300 3.2
Signaling
adenylate kinase (AK1) PF3D7_1008900 2.9
serine/threonine protein kinase PF3D7_1247500 2.4
serine/threonine protein kinase, FIKK family (FIKK9.3) PF3D7_0902200 2.4
GPI ethanolamine phosphate transferase 3 PF3D7_1214100 2.4
kinase PF3D7_0514800 2.3
GTP-binding protein PF3D7_1459100 15.1
conserved Plasmodium protein, unknown function PF3D7_1332200 7.1
protein kinase PF3D7_0926300 5.8
Rab GTPase activator and protein kinase PF3D7_0724000 5.1
ras GTPAse PF3D7_0616700 2.0
conserved Plasmodium protein, unknown function (PFA_0305c) mRNA, complete cds PFA_0305c -2.3
calcium-binding protein PF3D7_0605400 -2.3
14-3-3 protein PF3D7_1422900 -3.0
atypical protein kinase, ABC-1 family PF3D7_1414500 3.7
serine/threonine protein kinase, FIKK family, pseudogene (FIKK14) PF3D7_1476400 3.2
Surface/exported protein
Plasmodium exported protein, unknown function PF3D7_0532600 6.1
conserved Plasmodium protein, unknown function PF3D7_0721100 5.4
acyl-CoA-binding protein PF3D7_1119000 5.3
palmitoyltransferase PF3D7_1321400 5.1
conserved Plasmodium membrane protein, unknown function PF3D7_1216100 4.6
conserved Plasmodium protein, unknown function PF3D7_1229700 3.7
conserved Plasmodium membrane protein, unknown function PF3D7_1462600 3.4
rifin,PIR protein (RIF) PF3D7_1254800 2.6
conserved Plasmodium protein, unknown function PF3D7_1225700 2.4
erythrocyte binding antigen-181 (eba-181) mRNA, complete cds PFA_0125c 2.3
rifin,PIR protein (RIF) PF3D7_1400500 2.3
hemolysin III (HlyIII) PF3D7_1455400 2.1
Plasmodium exported protein, unknown function PF3D7_1252500 2.1
conserved Plasmodium membrane protein, unknown function PF3D7_0820600 12.0
conserved Plasmodium membrane protein, unknown function PF3D7_1142300 11.1
rifin,PIR protein (RIF) PF3D7_0937400 10.2
conserved Plasmodium protein, unknown function PF3D7_0918400 9.9
phosphatidylserine synthase PF3D7_1366800 8.8
conserved Plasmodium membrane protein, unknown function PF3D7_1324300 6.7
antigen 332, DBL-like protein (Pf332) PF3D7_1149000 5.0
erythrocyte membrane protein 1 (PfEMP1), exon 2 PF3D7_0223300 4.3 4.8
Plasmodium exported protein, unknown function, pseudogene PF3D7_1478700 3.4 5.8
rifin,PIR protein (RIF) PF3D7_0400900 3.1 -2.5
sporozoite invasion-associated protein 1 (SIAP1) PF3D7_0408600 3.1
conserved Plasmodium membrane protein, unknown function PF3D7_0721500 3.1
rifin,PIR protein (RIF) PF3D7_0223100 2.9
Plasmodium exported protein (hyp9), unknown function PF3D7_0220600 2.8
N6-adenine-specific methylase PF3D7_1350700 2.7
stevor,PIR protein PF3D7_1149900 2.6
rifin,PIR protein (RIF) PF3D7_0200600 2.6
Plasmodium exported protein (PHISTb), unknown function PF3D7_1201000 2.5
rifin,PIR protein (RIF) PF3D7_1300500 2.5
Pfmc-2TM Maurer's cleft two transmembrane protein (MC-2TM) PF3D7_1100800 2.5
conserved Plasmodium protein, unknown function PF3D7_0719100 2.3
Plasmodium exported protein (hyp15), unknown function PF3D7_0425200 2.1
stevor, pseudogene,PIR protein, pseudogene PF3D7_1100700 2.1
conserved Plasmodium membrane protein, unknown function

  • PF3D7_1411100.1

  • PF3D7_1411100.2

 -2.2
rifin,PIR protein (RIF) PF3D7_0413300 -2.2
conserved Plasmodium protein, unknown function PF3D7_1105800 -2.2
conserved Plasmodium protein, unknown function PF3D7_0318000 -2.3
conserved Plasmodium protein, unknown function PF3D7_0921500 -2.4
conserved Plasmodium membrane protein, unknown function PF3D7_0523700 -2.6
conserved Plasmodium membrane protein, unknown function PF3D7_1336300 -2.7
conserved Plasmodium protein, unknown function PF3D7_1002600 -3.0
conserved Plasmodium protein, unknown function PF3D7_1369600 -3.3
6-cysteine protein (B9) PF3D7_0317100 4.0
Trafficking
AP-4 complex subunit epsilon PF3D7_0904100 -2.4
Trafficking(mitochondrial)
mitochondrial import inner membrane translocase subunit TIM13 PF3D7_1242900 2.4
mitochondrial inner membrane TIM10 associated protein PF3D7_0502900 -2.1
Trafficking(vesicular)
transmembrane emp24 domain-containing protein PF3D7_0422100 6.2
CGI-141 protein homolog PF3D7_0419200 3.2
conserved Plasmodium protein, unknown function PF3D7_1107200 -3.8
ras-related protein RAB7 (RAB7) PF3D7_0903200 3.8
Transcription
DNA-directed RNA polymerase 2 8.2 kDa polypeptide PF3D7_0708100 4.3
DNA-directed RNA polymerase III subunit C PF3D7_1421400 2.2
conserved Plasmodium protein, unknown function PF3D7_0312000 2.6
conserved Plasmodium protein, unknown function PF3D7_1458800 3.4
Translation
translation initiation factor IF-1 PF3D7_1469000 4.3
eukaryotic translation initiation factor 3, subunit 6 PF3D7_0528200 2.8
tetQ family GTPase PF3D7_1235400 2.5
40S ribosomal protein S11 PF3D7_0317600 23.3
translation elongation factor EF-1, subunit alpha PF3D7_1123400 21.4 6.7
translation initiation factor IF-2 PF3D7_0607000 14.3
60S ribosomal protein L44 (RPL44) PF3D7_0304400 13.1 4.1
60S ribosomal protein L24 PF3D7_1309100 6.8
cysteine—tRNA ligase

  • PF3D7_1015200.1

  • PF3D7_1015200.2

  • PF3D7_1015200.3

 4.8 3.1
nucleic acid binding protein PF3D7_1132300 4.8
peptide chain release factor PF3D7_0704900 4.6
mitochondrial ribosomal protein L28 precursor, PF3D7_1456600 -2.8
Translation;RNA
rRNA processing and telomere maintaining methyltransferase PF3D7_0925200 8.0
Transport
vacuolar proton translocating ATPase subunit A PF3D7_0806800 3.6
conserved membrane protein, unknown function PF3D7_0719500 11.4 5.3
ABC transporter, (CT family) (MRP2) PF3D7_1229100 7.6
CorA-like Mg2+ transporter protein, PF3D7_1304200.2 6.0
mitochondrial carrier protein PFA_0415c -2.5
Ubiquitin
sentrin-specific protease 1 (SENP1) PF3D7_1233900 4.5
conserved Plasmodium protein, unknown function PF3D7_1442800 -2.3
ubiquitin fusion degradation protein 1 (UFD1) PF3D7_0916500 14.8
ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCHL3) PF3D7_1460400 4.0
RING zinc finger protein PF3D7_0209700 2.9
ubiquitin (Ub) PF3D7_0815700 -2.3
ubiquitin carboxyl-terminal hydrolase PF3D7_1414700 -3.1
cullin-like protein PF3D7_0629800 -2.4
Apicomplexia only
conserved Plasmodium protein, unknown function PF3D7_1009900 6.0
conserved Plasmodium protein, unknown function PF3D7_1407700 4.7
conserved Plasmodium protein, unknown function PF3D7_1228400 9.0 8.7
Plasmodium only
conserved Plasmodium protein, unknown function PF3D7_0506400 2.1
conserved Plasmodium protein, unknown function PF3D7_0517100 -2.1
conserved Plasmodium protein, unknown function PF3D7_1031100 -2.4
conserved Plasmodium protein, unknown function PF3D7_0708200 9.4 3.7
conserved Plasmodium protein, unknown function PF3D7_0802900 -2.3
conserved Plasmodium protein, unknown function PF3D7_1465600 -2.3
conserved Plasmodium protein, unknown function PF3D7_1137600 -2.7
conserved Plasmodium protein, unknown function PF3D7_1413100 -3.2
conserved Plasmodium protein, unknown function PF3D7_1362800 3.7
conserved Plasmodium protein, unknown function PF3D7_1018100 19