Table 4. Acute and long-term outcomes of PV isolation using RF versus the cryoballoon in non-randomized studies.
*Combination of first- and second-generation cryoballoons, **Second-generation cryoballoon only, †Force sensing RF
| Study | n | Paroxysmal AF | Acute PV isolation | Ablation Time, min | Procedure time, min | Fluoroscopy time, min | PN palsy | Other adverse events | Freedom from AF during long-term follow-up |
|---|---|---|---|---|---|---|---|---|---|
| Linhart, et al.[68] RF Cryoballoon | 20 20 | 20 (100%) 20 (100%) | 100% 81% | N/A N/A | 200 ± 67 166 ± 39 | 55 ± 23 41 ± 13 | 0% 15% | 0% 0% | 45% at 6 months 50% at 6 months |
| Kojodjojo, et al.[69] RF Cryoballoon | 53 90 | 53 (100%) 90 (100%) | 99% 83% | N/A N/A | 208 ± 58 108 ± 28 | 62 ± 36 27 ± 9 | 0% 2.2% | 3.8% 1.1% | 72% at 1 year 77% at 1 year |
| Tayebjee, et al.[70] RF Cryoballoon | 25 25 | 25 (100%) 25 (100%) | 100% 76% | N/A N/A | 35 45 | 0% 8% | 0% 4% | 4% 4% | 52% at 1 year 56% at 1 year |
| Kühne, et al.[71] RF Cryoballoon | 25 25 | 25 (100%) 25 (100%) | 00% 100% | 47 45 | 197 ± 52 166 ± 32 | 46 ± 22 61 ± 25 | 0% 4% | 4% 4% | 92% at 1 year 88% at 1 year |
| Sorgente, et al.[72] RF Cryoballoon | 29 30 | 20 (69%) 24 (80%) | 100% 100% | N/A N/A | N/A N/A | N/A N/A | 0% 10% | 13.8% 3.3% | 66% at 1 year 66% at 1 year |
| Herrera Siklódy, et al.[73] RF Cryoballoon | 30 30 | 17 (57%) 21 (70%) | 100% 100% | 52 ± 21 44 ±6 | 200 ± 46 177 ± 30 | 37 ± 16 38 ± 12 | 0% 6.7% | 0% 6.7% | 80% at 1 year 63% at 1 year |
| Schmidt, et al.[74] RF Cryoballoon | 2,870 905 | 2,870 (100%) 905 (100%) | 98% 97% | 33 45 | 165 160 | 24 34 | 0% 2.1% | 4.6% 2.7% | N/A N/A |
| Mugnai, et al.[75] RF Cryoballoon | 260 136 | 260 (100%) 136 (100%) | 100% 100% | 43 ± 6 45 ± 4 | 192 ± 49 112 ± 58 | 36 ± 14 31 ± 17 | 0% 8.1% | 14.2% 11.0% | 57% at 23 months 63% at 23 months |
| Juliá, et al.[76] RF† Cryoballoon* | 186 100 | 186 (100%) 100 (100%) | 98% 100% | N/A N/A | 190 ± 57 117 ± 59 | 35 ± 19 27 ± 16 | N/A N/A | N/A N/A | 80% at 1 year 81% at 1 year |
| Aryana, et al.[58] RF Cryoballoon** | 422 633 | 319 (76%) 472 (75%) | 99% 98% | 66 ± 26 40 ± 14 | 188 ± 42 145 ± 49 | 23 ± 14 29 ± 1 | 0% 7.6% | 2.6% 1.6% | 60% at 1 year 77% at 1 year |
| Jourda, et al.[79] RF† Cryoballoon** | 75 75 | 75 (100%) 75 (100%) | 100% 100% | 2 ± 13 32 ± 3 | 111 ± 32 134 ± 48 | 21 ± 8 25 ± 10 | 0% 17.3% | 2.7% 1.3% | 88% at 1 year 85% at 1 year |