Fig. 3.

Study 1.1. Bone Mapping (CBM) ROIs. Statistically significant differences in cortical (a) and trabecular (b) bone between hip fracture (n = 70, 50 female, 20 male) and 70 healthy controls shown as a colour map on the canonical femur model. CMSD Cortical Mass Surface Density, ECTD Endocortical Trabecular Density Study 1.2. Cortical (c) and trabecular (d) differences between female femoral neck patients (n = 86) and controls (n = 125). Cortical (e) and trabecular (f) differences between female trochanteric fracture patients (n = 52) and controls (n = 125). The black arrow highlights the biopsy site for Study 2.1. Study 1.3. Cortical (g) differences between frail female patients with at least one injurious fall (n = 50) versus 50 healthy controls (no difference in trabecular bone (h)).