Skip to main content
. 2016 Aug 24;5(10):e1224044. doi: 10.1080/2162402X.2016.1224044

Figure 4.

Figure 4.

Selective signaling defects following FL CD8+ TIM-3+ T cell stimulation. Representative histogram overlay (A) and pooled datas (B) of CD8+TIM-3+ and CD8+TIM-3−T cells staining for phosphorylated ERK (pERK) and AKT (T308 and S473) (pAKTs), (MFI), after 15 min of PMA/ion stimulation (n = 7). Representative histogram overlay (C) and pooled datas (D) of CD8+TIM-3+ and CD8+ TIM-3− T cell staining for pERK after 15 min of TCR triggering (n = 4). Paired Student's t-test using the GraphPad Prism software (version 6; GraphPad) was used to determine the statistical significance of differences between the groups. p = 0.0488 (B); p = 0.0422 (D).