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. 2016 Oct 31;113(46):13209–13214. doi: 10.1073/pnas.1616206113

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Fig. 1. — IM-AA mutation reduces LTP in SC-CA1 synapses. (A) LTP induced at −40 mV by eight trains of θ-burst stimulation (10 bursts delivered at 5 Hz, each burst consisted of 10 pulses at 100 Hz) from WT (black, n = 6) and IM-AA (red, n = 7) (Left). LTP values from individual cells (open symbols) and average LTP values (solid symbols) from WT (black) and IM-AA (red) (Right). (B) LTP induced by two 100-Hz trains at −60 mV in the presence of 1 μM ω-Ctx, 50 μM picrotoxin, and 10 μM CGP55845 hydrochloride from WT (black, n = 8) and IM-AA (red, n = 8) (Left). (Right) Summarized LTP values as in A. (C) LTP induced by two 100-Hz trains at 0 mV in the presence of 1 μM ω-Ctx, 50 μM picrotoxin, and 10 μM CGP55845 hydrochloride from WT (black, n = 7) and IM-AA (red, n = 6) (Left). (Right) Summarized LTP values as in A. *P < 0.05; ***P < 0.001.