Fig. S7.

Ca²⁺ wave propagation with a two-state hemichannel model. (A) Two-state model of a connexin hemichannel. The model comprises a closed (C) and an open (O) state. (B) Hemichannel open probability as a function of [Ca²⁺]_c (blue line) for the two-state hemichannel model. Black squares represent the data used to fit the four-state model in Fig. 1 of the main text. (C) The maximal radius of Ca²⁺ waves triggered by focal ATP application plotted against time for different values of $v_{\text{HC}}$ (0.0, 200.0, and 2,000.0 μM·s⁻¹) at constant $r_{\text{deg}}^{\text{ATP}}$ = 0.001 s⁻¹. For the two-state hemichannel model, k₁ = 30 µM⁻¹·s⁻¹, k₋₁ = 1 s⁻¹. For all other model parameters, see Table S1.