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Structural basis for selectivity and binding of WT161 to HDAC6. (A) Screening of the hydrazine library in a high-content imaging assay to identify the cellular effects of potential HDAC inhibitors. The activity of WT161 (red) and compound 1 (gray) are shown. (B) Sequence alignment of the key loop region of HDAC2, -3, and -6. (C) Interaction diagram for WT161 bound to HDAC6. Relevant interactions with Arg194 and Phe200 are depicted.
