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WT161 with BTZ is effective in overcoming resistance. (A) RPMI8226 cells were cocultured with BMSCs ± WT161 with increasing concentrations of BTZ for 24 h. Cell proliferation was assessed by [3H]-thymidine uptake; n = 3. (B) Myeloma tumor cells from patients resistant to BTZ treatment were treated with WT161 in the presence or absence of BTZ. Cytotoxicity was assessed by MTT assay from triplicate cultures. Data represent the mean ± SD.
