Table S1.
Biochemical inhibitory activity of SAHA, WT161, and tubacin against HDAC1–9
| SAHA | WT161 | Tubacin | ||||
| HDAC isoform | Mean IC50, nM | 95% confidence interval | Mean IC50, nM | 95% confidence interval | Mean IC50, nM | 95% confidence interval |
| HDAC1 | 0.09 | 0.06–0.14 | 8.35 | 5.37–12.97 | 14.5 | 9.99–21.08 |
| HDAC2 | 0.19 | 0.16–0.23 | 15.4 | 12.66–18.70 | 27.8 | 21.95–35.13 |
| HDAC3 | 0.21 | 0.16–0.28 | 51.6 | 36.27–73.44 | 130.9 | 94.37–181.5 |
| HDAC4 | — | — | — | |||
| HDAC5 | — | — | — | |||
| HDAC6 | 0.035 | 0.026–0.046 | 0.40 | 0.28–0.55 | 1.62 | 1.12–2.32 |
| HDAC7 | — | — | — | |||
| HDAC8 | 142.6 | 107.5–189.2 | 1,430 | 881.2–2327 | 943.0 | 644.4–1,382 |
| HDAC9 | — | — | — | |||
—, IC50 >10 μM.