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. 2016 Oct 31;113(46):E7240–E7249. doi: 10.1073/pnas.1608555113

Fig. S2.

Fig. S2.

(A) CT26 cells were injected s.c. in the flank of BALB/c mice (n = 6 per group) on day −5. SD-101 or CTRL-ODN were administered IT on days 0, 3, 7, 10, 14, 17, and 22. On day 25 (3 d after last treatment), the group injected with the CTRL-ODN was killed due to excessive enlarged tumors. On day 35 (13 d after the last treatment), the group injected with SD-101 was killed. Mean is mean tumor volume of six mice per treatment group. Tumor volume (mm3) was calculated according to the formula: (width)2 × length/2. Two out of six mice were able to completely reject the tumors (33% rate of complete response). (B) The gene induction from the respective excised tumors analyzed for day 25 (CTRL-ODN) and day 35 (SD-101) is presented. Data are represented as relative threshold cycle (CT) of the gene of interest relative to the housekeeping gene, Ubiquitin. Mean is mean relative counts of six mice per treatment group.