Table 2.
Comparative reports of EPP and P/D in malignant pleural mesothelioma
| Study | N | Notable outcomes | Comments |
|---|---|---|---|
| Flores et al33 | 663 | P/D associated with improved median survival and operative mortality vs EPP | Limited by selection bias at three institutions |
| Lang-Lazdunski et al35 | 75 | Median OS 23 months for e-P/D vs 12.8 months for EPP. No perioperative mortality with e-P/D | Prospective single-institution experience |
| IASLC34 | 3,101 | EPP associated with improved survival vs P/D in stage I patients only | Selection bias, data limitations, and small number of stage I patients to compare |
| Cao et al36 | 1,145 | Lower perioperative mortality and morbidity with e-P/D. Unable to compare survival outcomes | Meta-analysis |
| Taioli et al37 | 2,903 | 2.5-fold lower 30-day mortality with P/D; similar 2-year survival for P/D and EPP | Meta-analysis; survival analysis limited by data heterogeneity |
Abbreviations: IASLC, International Association for the Study of Lung Cancer; EPP, extrapleural pneumonectomy; e-P/D, extended pleurectomy/decortication; P/D, pleurectomy/decortication.