Table 1.

Resources being generated through the American Heart Association Hypertension Strategically Focused Research Network.

Hypertension SFRN Center	Data being collected/resources being generated
Cincinnati Children’s Hospital (n=500, age 13–17 years, ~1/3 non-Caucasian; same cohort for all projects)
Population science project	Echocardiogram for left ventricular mass, diastolic function, strain, pulse wave velocity, urine for microalbumin, cognitive function tests, questionnaires: food frequency, exercise, socioeconomic status
Clinical science project	Casual/office BP, Ambulatory BP monitoring, metabolic parameters (lipids, insulin, glucose)
Basic science project	DNA methylation and micro RNAs related to hypertension and cardiac fibrosis
Medical College of Wisconsin
Population science project (original African American cohort n=3,000; 50% w/hypertension)	Follow-up blood pressure and 10–20 year cardiovascular morbidity and mortality events; base-resolution DNA methylation data
Clinical science project Aim 1: Identical twins: ~300 pairs Aim 2: Unrelated subjects: ~60 subjects	Aim 1: Questionnaires (activity level, socioeconomic status, sodium screener, anthropometrics, blood pressure levels, blood and urine for electrolytes, and DNA from various cellular components. Aim 2: All of the above parameters, 24 hour urine collection for electrolytes pre- and post-low sodium diet. Base-resolution DNA methylation data in both aims.
Basic science project	Sodium-dependent and –independent effects on arterial blood pressure, heart rate, renal disease phenotypes, RNA expression and DNA methylation in T lymphocytes in the circulation and the kidney, and the expression of cytokines in the T lymphocytes.
University of Alabama at Birmingham
Population science project  (n=700; 350 whites; 350 African Americans)	Ambulatory blood pressure monitoring, actigraphy, sleep questionnaires, psychosocial questionnaires for CARDIA participants
Clinical science project  (n=60; 30 whites and 30 African Americans)	Four home sleep studies, four 24-hour urine collections, four ambulatory blood pressure monitoring periods, renin, aldosterone and buccal cell collections of CARDIA participants with nocturnal hypertension
Basic science project	Circadian blood pressure, heart rate, activity monitoring in genetically modified Dahl salt-sensitive rats as well as diurnal sodium excretion patterns. Expression of clock genes in buccal cells from clinical project.
University of Iowa
Population science project	Iowa SFRN Population Study Bank: First trimester maternal blood and urine that are deeply clinically annotated from hospitals throughout the state of Iowa spanning different socioeconomic and racial distributions.
Clinical science project (n=248 pregnant women; n=124 with high copeptin and n=124 with low copeptin)	In vivo data obtained in pregnant women once each trimester and 6 weeks postpartum including: brachial artery flow-mediated dilation, pulse wave velocity, central blood pressure, augmentation index, common carotid artery compliance, cardiac baroreflex sensitivity, 24-hr ambulatory blood pressure, lipids/glucose, plasma/serum for vasopressin, copeptin, and pregnancy outcome data.
Basic science project	Development of novel clinically-relevant animal models, and exploration of clinical drug repurposing for use in preeclampsia. Blood pressure, renal, vascular, and immune functions in preeclampsia. Human blood and tissue samples made possible through interactions with Clinical and Population projects.

CARDIA – Coronary artery risk development in young adults.